Joey DeFrancesco was born in 1971 in Springfield, Pennsylvania. He was born into a musical family that included three generations of jazz musicians. He was named after his grandfather, Joseph DeFrancesco, a jazz musician who played the saxophone and clarinet. His father, “Papa” John DeFrancesco, was an organist who played nationally and received the Oklahoma Jazz Hall of Fame’s Living Legend Award in 2013. DeFrancesco began playing the organ at the age of 4 and was playing songs by Jimmy Smith verbatim by the time he was 5. His father John began bringing him to gigs from the age of 5, letting him sit in on sets. At the age of 10, DeFrancesco joined a band in Philadelphia that included jazz legends Hank Mobley and Philly Joe Jones. He was considered a fixture at local jazz clubs, opening shows for Wynton Marsalis and B.B. King.
DeFrancesco attended the Philadelphia High School for the Creative and Performing Arts. During his high school years, DeFrancesco won numerous awards, including the Philadelphia Jazz Society McCoy Tyner Scholarship. He was also a finalist in the first Thelonious Monk International Jazz Piano Competition.